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INDEX OF TOPICS
BASIC IMMUNOLOGY
LECTURE 1 (60 MINUTES)
A STRUGGLE FOR SURVIVAL
Foundation of the
immune system
Extracellular pathogens
Intracellular pathogens
Lysozyme
Phagocytosis
Neutrophils
Monocytes
Eosinophils
Complement
Interferon
Natural killer cells
Cytotoxicity
Antibodies
B-cell receptors
T-cell receptors
Innate immune system
Specific immune system
Mannose-binding protein
C-reactive protein
B-lymphocytes
T-lymphocytes
Complement activation
Mediator release
Antibody-dependent cytotoxcity
Opsonization
Simple neutralization
Fc portion of antibody
Fab portion of antibody
Memory
LECTURE 2 (90
MINUTES)
THE 3 ORANGE CIRCLES
Monoclonal
Polyclonal
Antigen
Epitope
Protein
Monoclonal gammopathy
Protein electrophoresis
Alphabetalization
VDJ rearrangement
Lymphoid ambassadors
Clonal selection
Clonal expansion
Lymphoid clubs
Secondary lymphoid organs
Lymph nodes, spleen, MALT
Lymphocyte homing (Broadcast-satellite systems)
High endothelial venules
Endothelial cells
Adhesion molecules
Lymphatic drainage
Selectins
Ig superfamily
Integrins
Mucins
Somatic hypermutation
Immunoglobulin class switch
Antigen driven responses
Innocent (bystander) effect
HCV versus RA
LECTURE 3 (90 MINUTES)
THE PRICE OF HIGH TECH
Antigen processing
Antigen presentation
Haptens
Major histocompatibility complex (HLA)
MHC I and MHC II
CD4 and CD8
Central tolerance
Peripheral tolerance
Helper T cells
Cytotoxic T cells
IFN-gamma, IL-2
IL-4, IL-6, IL-10, IL-13
TH0, TH1 and TH2 cells
Why RA remits during pregnancy
Inborn cyclosporine mechanisms
TH1/TH2 balance
Faculative intracellular pathogens
Obligate intracellular pathogens
Cell-mediated macrophage responses
MHC I downregulation & NK cells
LECTURE 4 (90 MINUTES)
THE MHC, AN OPINIONATED PROTEIN
MHC opinionated in quantity
MHC opinionated in quality
Many opinions are genetically determined
MHC and disease
Critical and non-critical peptides
Immune distraction
Immune concentration
Duchenne Muscular dystrophy heritance
Survival friendly MHCs
West Africans and malaria
MHC mutations
Gamal Hemdan and the MHC
Endogenous antigen processing
Exogenous antigen processing
MHC co-alleles
MHC diversity
AFA vs face protocol
Backbone vs side-chain protocol
The binding groove
Amino acid cassettes
The shared epitope and autoimmune diseases
T-cell independent B-cell responses
LECTURE 5 (90
MINUTES)
REVISION
CLINICAL IMMUNOLOGY
LECTURE 6 (60 MINUTES)
HYPERSENSITIVITY REACTIONS TYPES I AND II
Primary and secondary immune responses
Immune complexes
Macrophage-complement system
Macrophages and TH1 cells
Hypersensitivity definition
IgE instead of IgG
Mast cells
Basophils
Histamine
Serotonin
Prostaglandins
Urticaria
Rhinitis
Anaphylaxis
Atopy
In situ immune complexes
Autoimmune hemolytic anemia
LECTURE 7 (60
MINUTES)
HYPERSENSITIVITY REACTIONS TYPES III AND IV
Immune complex clearance
CR1 receptors
Antigen antibody complexes
Size of immune complexes
Complement deficiency
Phagocytic cell defects
Vasoactive amines
Charge of immune complexes
Post-streptococcal glomerulonephritis
Systemic lupus Farmer's lung
IL-12
TNF alpha
Contact hypersensitivity
Tuberculin hypersensitivity
Histoplasmosis
Granuloma formation
Giant cells
Sarcoidosis
LECTURE 8 (60
MINUTES)
AUTOIMMUNITY
The lupus era
The pernicious era
Autoimmunity
Tolerance
Maturity of the immune system
Primary lymphoid organs
Bone marrow
Thymus
Selection processes
Central and peripheral tolerance
Negative selection
Ignorance or no selection
Positive selection
Clonal anergy
Activation induced cell death
Checking Isotype switch
Compensatory mechanisms for somatic mutation
Genesis of autoimmunity
Breakdown of tolerance
CD28 and CD40
CTLA-4
Cytokine imbalances
Apoptosis
Molecular mimicry
Complement deficiency
Sequestered antigens
Immunologically privileged sites
Organ specific autoimmunity
Non-organ specific autoimmunity
LECTURE 9 (60
MINUTES)
AUTOIMMUNE RHEUMATIC DISEASES
Pathogenesis of Rheumatoid Arthritis
Pathogenesis of Ankylosing Spondylitis
Pathogenesis of Crohn's disease
Pathogenesis of psoriatic arthritis
LECTURE 10 (60
MINUTES)
BIOLOGICAL AGENTS
Inhibitors of TNF alpha
Inhibitors of IL-1
Inhibitors of IL-6
Inhibitors of CD-20
CTLA-4
Other biological agents
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